Impact of Drug-Gene Interactions on Patients’ Outcome

Seegnal Case Studies 2020

Drug–drug interactions (DDIs) are a well-known cause of drug-related problems (DRPs),
but two other newly described types of interactions are also involved in DRPs: Drug–gene
and drug–drug–gene interactions. Both are considered to have a significant impact on
patients’ wellbeing and treatment outcome.

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• About 20% of the population present genetic polymorphism
• Patient’s genetic polymorphism impacts the ability to metabolize certain drugs
• Everyday drugs can react with patients’ genes to cause DRPs