Drug–drug interactions (DDIs) are a well-known cause of drug related problems (DRPs). Drug interaction databases and software are used as a primary tool to alert clinicians of potential DDIs and DRPs. But various software solutions provide different results to the same question, as there is no standard to define a DDI. Even more importantly, they may provide only partial results, as multiple studies demonstrate that up to 33% of relevant DDIs are not detected by dedicated software.
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